GLP-1 medications are not safe during pregnancy. If you are pregnant, planning to become pregnant, or suspect you might be pregnant, you should not use GLP-1 drugs.
Why GLP-1s are contraindicated in pregnancy
Animal studies have shown potential risks to fetal development with GLP-1 receptor agonists. Because of this, all current GLP-1 medications carry warnings against use during pregnancy.
This applies to:
- Wegovy (injection and pill)
- Zepbound
- Ozempic
- Mounjaro
- Foundayo
- Saxenda
When to stop
Most providers recommend stopping GLP-1 medication at least 2 months before trying to conceive. The exact washout period may vary by medication:
- Semaglutide (Wegovy, Ozempic): stop at least 2 months before conception
- Tirzepatide (Zepbound, Mounjaro): stop at least 2 months before conception
- Orforglipron (Foundayo): follow your provider’s guidance as data is still emerging
- Liraglutide (Saxenda): stop at least 1 month before conception
What to discuss with your provider
If you are on GLP-1 medication and considering pregnancy:
- When to stop the medication
- How to manage weight during the washout period
- Alternative approaches during pregnancy
- Whether to resume after delivery and breastfeeding
Breastfeeding
There is limited data on GLP-1 use during breastfeeding. Most providers advise against it until more safety data is available.
An important note
Some patients have reported unexpected pregnancies after starting GLP-1 medication. Weight loss can restore ovulation in women with conditions like PCOS, increasing fertility. If pregnancy is not your goal, use reliable contraception while on treatment.
Bottom line
Stop GLP-1 medications before trying to get pregnant. Talk to your provider about timing, washout periods, and safe alternatives during pregnancy and breastfeeding.
Medical disclaimer: This content is for informational purposes only and is not medical advice. Consult a licensed healthcare provider before starting any treatment.
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