This chart compares all major weight loss medications available in the United States in 2026, including the newest GLP-1 pills.
Quick comparison
Wegovy (injection)
- Type: Weekly injection
- Active ingredient: Semaglutide
- Mechanism: GLP-1 receptor agonist
- Avg weight loss: ~15%
- Cost without insurance: $900-$1,300/month
- FDA approved for weight loss: Yes
Wegovy (pill)
- Type: Daily oral tablet
- Active ingredient: Semaglutide
- Mechanism: GLP-1 receptor agonist
- Avg weight loss: ~16.6%
- Cost without insurance: $149/month intro, then higher
- FDA approved for weight loss: Yes (December 2025)
Foundayo
- Type: Daily oral tablet
- Active ingredient: Orforglipron
- Mechanism: Non-peptide GLP-1 receptor agonist
- Avg weight loss: ~12.4%
- Cost without insurance: TBD (launched April 2026)
- FDA approved for weight loss: Yes (April 2026)
Zepbound
- Type: Weekly injection
- Active ingredient: Tirzepatide
- Mechanism: Dual GLP-1/GIP receptor agonist
- Avg weight loss: ~20-22%
- Cost without insurance: $1,000-$1,400/month
- FDA approved for weight loss: Yes
Ozempic
- Type: Weekly injection
- Active ingredient: Semaglutide
- Mechanism: GLP-1 receptor agonist
- Avg weight loss: ~12-15%
- Cost without insurance: $900-$1,200/month
- FDA approved for weight loss: No (off-label use)
Contrave
- Type: Daily oral tablet
- Active ingredient: Naltrexone/bupropion
- Mechanism: Appetite and reward pathway modulation
- Avg weight loss: ~5-9%
- Cost without insurance: $200-$400/month
- FDA approved for weight loss: Yes
Qsymia
- Type: Daily oral capsule
- Active ingredient: Phentermine/topiramate
- Mechanism: Appetite suppression
- Avg weight loss: ~8-10%
- Cost without insurance: $150-$300/month
- FDA approved for weight loss: Yes
Saxenda
- Type: Daily injection
- Active ingredient: Liraglutide
- Mechanism: GLP-1 receptor agonist
- Avg weight loss: ~5-8%
- Cost without insurance: $1,000-$1,300/month
- FDA approved for weight loss: Yes
Key takeaways
- Strongest weight loss: Zepbound (tirzepatide)
- Best new pill option: Oral Wegovy (semaglutide)
- Most affordable pill: Contrave or Qsymia
- Best for dual diabetes + weight loss: Ozempic or Mounjaro (off-label)
- Newest entry: Foundayo (orforglipron, April 2026)
Bottom line
The right medication depends on your medical profile, budget, side effect tolerance, and whether you prefer pills or injections. This chart is a starting point — work with your provider to choose the best fit.
Medical disclaimer: This content is for informational purposes only and is not medical advice. Consult a licensed healthcare provider before starting any treatment.
Health Disclaimer: BestMedsHub is not a healthcare provider, telehealth service, pharmacy, or medical organization. We do not prescribe medication, diagnose conditions, render medical opinions, or facilitate clinical consultations. All content is for general informational and comparison purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified physician, pharmacist, or other licensed healthcare professional before starting, stopping, or changing any treatment, medication, supplement, or health program. Never disregard professional medical advice or delay seeking it because of anything you have read on this site. If you think you may have a medical emergency, call your local emergency number immediately.
FDA & Prescription Medication Disclaimer: Prescription medications referenced on this page are available only through a licensed healthcare provider after a clinical evaluation, and may not be appropriate or safe for everyone. Any statements regarding dietary supplements, wellness products, or off-label uses have not been evaluated by the U.S. Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary and are not guaranteed. Always read the medication guide and consult your prescriber and pharmacist about side effects, contraindications, and drug interactions.
